Delta14-Triamcinolone acetonide

Delta14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.Formal Name: (6aS,6bR,7S,8aS,8bS,11aR,12bS)-6b-fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12b-decahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one. CAS Number: 1260149-96-9. Synonyms: 14,15-dehydro Triamcinolone acetonide, Triamcinolone acetonide Impurity B. Molecular Formula: C24H29FO6. Formula Weight: 432.5. Purity: >96%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 238 nm. SMILES: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)C3=C[C@]5([H])[C@@]4(C(CO)=O)OC(C)(C)O5)=C1. InChi Code: InChI=1S/C24H29FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-10,15,17,19,26,28H,5-6,11-12H2,1-4H3/t15-,17-,19+,21-,22-,23-,24+/m0/s1. InChi Key: ZIASJPXEBODFKN-VZFRDGCYSA-N.