D-NMAPPD

D-NMAPPD is an inhibitor of ceramidase. It induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner but has no effect on viability of rat hepatocytes, Kupffer cells, or sinusoidal endothelial cells when used at a concentration of 100 mM. D-NMAPPD increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells, effects that can be prevented by the caspase-3 inhibitor Ac-DEVD-CHO (Cay-10017). In vivo, D-NMAPPD (75 mg/kg) reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models.Formal Name: N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide. CAS Number: 35922-06-6. Synonyms: (1R,2R)-B13, CAY10466. Molecular Formula: C23H38N2O5. Formula Weight: 422.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:2): .3 mg/ml. lambdamax: 202, 275 nm. SMILES: OC[C@@H](N([H])C(CCCCCCCCCCCCC)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1. InChi Code: InChI=1S/C23H38N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-22(27)24-21(18-26)23(28)19-14-16-20(17-15-19)25(29)30/h14-17,21,23,26,28H,2-13,18H2,1H3,(H,24,27)/t21-,23-/m1/s1. InChi Key: XUSDVLHKNBOGJY-FYYLOGMGSA-N.