Ciprostene (calcium salt)

Ciprostene is the 9beta-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively.Formal Name: 6,9alpha-methylene-9beta-methyl-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monocalcium salt. CAS Number: 81703-55-1. Synonyms: Ciprostene calcium, U-61431F. Molecular Formula: [C22H35O4]2 . Ca2+. Formula Weight: 767.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 16.8 mg/ml, ethanol: 34 mg/ml, PBS pH 7.2: 0.29 µg/ml. SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@]2(C)[C@@H]1C/C(C2)=C/CCCC([O-])=O.CCCCC[C@H](O)/C=C\[C@H]3[C@H](O)C[C@@]4(C)[C@@H]3C/C(C4)=C\CCCC([O-])=O.[Ca+2]. InChi Code: InChI=1S/3C22H36O4.Ca/c3*1-3-4-5-9-17(23)11-12-18-19-13-16(8-6-7-10-21(25)26)14-22(19,2)15-20(18)24,/h3*8,11-12,17-20,23-24H,3-7,9-10,13-15H2,1-2H3,(H,25,26),/q,,,+2/p-3/b3*12-11+,16-8-,/t3*17-,18+,19+,20+,22-,/m000./s1. InChi Key: FWIIJCPYORKGGH-LOWTZELISA-K.