CAY10662

17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by beta-adrenergic agonists (EC50 = ~ 1-2 nM). CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 µM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.Formal Name: 16-[[(ethylamino)carbonyl]amino]-11Z-hexadecenoic acid. CAS Number: 1184844-74-3. Molecular Formula: C19H36N2O3. Formula Weight: 340.5. Purity: >98%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 3 mg/ml, Ethanol: 2 mg/ml. SMILES: CCNC(NCCCC/C=C\CCCCCCCCCC(O)=O)=O. InChi Code: InChI=1S/C19H36N2O3/c1-2-20-19(24)21-17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18(22)23/h7,9H,2-6,8,10-17H2,1H3,(H,22,23)(H2,20,21,24)/b9-7-. InChi Key: OUFBVXMGWWCVFO-CLFYSBASSA-N.