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CAY10444 is a sphingosine-1-phosphate receptor 3 (S1P3) antagonist. It inhibits S1P-induced calcium mobilization in CHO cells expressing human S1P3 (IC50 = 11.6 µM). CAY10444 (5 µM) inhibits S1P-induced growth and migration of MH7A rheumatoid fibroblast-like synoviocyte cells. It inhibits the localization and release of IL-1beta and prostaglandin E2 (PGE2, Cay-14010) in MH7A cells when used at a concentration of 5 µM. CAY10444 (17.4 µM) also inhibits Na+/K+-ATPase activity in HepG2 cells.Formal Name: 2-undecyl-4R-thiazolidinecarboxylic acid. CAS Number: 298186-80-8. Synonyms: BML-241. Molecular Formula: C15H29NO2S. Formula Weight: 287.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.15 mg/ml. SMILES: [H]N1C(CCCCCCCCCCC)SC[C@H]1C(O)=O. InChi Code: InChI=1S/C15H29NO2S/c1-2-3-4-5-6-7-8-9-10-11-14-16-13(12-19-14)15(17)18/h13-14,16H,2-12H2,1H3,(H,17,18). InChi Key: FNBSOIBCKUUVJJ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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