Caudatin

Caudatin is a C-21 steroid that has been found in C. auriculatum and has anticancer activity. It is cytotoxic to SMMC-7721, MCF-7, and HeLa cells (IC50s = 24.95, 65.82, and 247.54 µM, respectively). Caudatin (50-300 µM) induces apoptosis in and inhibits mammosphere formation by MDA-MB-231 breast cancer cells, as well as decreases the number of cancer stem cells (CSCs) in the MDA-MB-231 cell population. In vivo, caudatin (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model.Formal Name: (3beta,12beta,14beta,17alpha)-12-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-3,8,14,17-tetrahydroxy-pregn-5-en-20-one. CAS Number: 38395-02-7. Molecular Formula: C28H42O7. Formula Weight: 490.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 220 nm. SMILES: C[C@@]12[C@@]([C@]3([C@]([C@@]4(C(C[C@H](CC4)O)=CC3)C)([H])C[C@H]1OC(/C=C(C)/C(C)C)=O)O)(CC[C@@]2(O)C(C)=O)O. InChi Code: InChI=1S/C28H42O7/c1-16(2)17(3)13-23(31)35-22-15-21-24(5)9-8-20(30)14-19(24)7-10-27(21,33)28(34)12-11-26(32,18(4)29)25(22,28)6/h7,13,16,20-22,30,32-34H,8-12,14-15H2,1-6H3/b17-13+/t20-,21+,22+,24-,25+,26+,27-,28+/m0/s1. InChi Key: VWLXIXALPNYWFH-UXGQNDOZSA-N. Origin: Plant/Cynanchum otophyllum.