Bromfenac-d4 (sodium salt)

Bromfenac-d4 is intended for use as an internal standard for the quantification of bromfenac (Cay-23763) by GC- or LC-MS. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2, IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM). It inhibits prostaglandin E2 (PGE2, Cay-14010) production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks. Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.Formal Name: 2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneacetic acid, monosodium salt. CAS Number: 2749400-35-7. Molecular Formula: C15H7BrD4NO3 . Na. Formula Weight: 360.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 5 mM, Water: 100 mM. SMILES: BrC1=C([2H])C([2H])=C(C(C2=CC=CC(CC([O-])=O)=C2N)=O)C([2H])=C1[2H].[Na+]. InChi Code: InChI=1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19,/h1-7H,8,17H2,(H,18,19),/q,+1/p-1/i4D,5D,6D,7D,. InChi Key: HZFGMQJYAFHESD-OAIJHCBKSA-M.