AMG 319

AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform delta (PI3Kdelta, IC50 = 18 nM) that less effectively targets the alpha, beta, and gamma isoforms (IC50s = 33, 2.7, and 0.85 µM, respectively). It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells. AMG 319 is orally bioavailable and reduces inflammation in two animal models.Formal Name: 7-fluoro-alphaS-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine. CAS Number: 1608125-21-8. Molecular Formula: C21H16FN7. Formula Weight: 385.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/mL, DMSO: 5 mg/mL, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL, Ethanol: 3 mg/mL. lambdamax: 267 nm. SMILES: C[C@@H](C1=CC(C=CC(F)=C2)=C2N=C1C3=CC=CC=N3)NC4=C5C(N=CN5)=NC=N4. InChi Code: InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1. InChi Key: KWRYMZHCQIOOEB-LBPRGKRZSA-N.