AM404

AM404 is an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons. AM404 selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis. It inhibits the transport of AEA with an IC50 of 1 µM in rat neurons and 5 µM in rat astrocytes. In in vivo models, AM404 enhances and prolongs exogenous AEA-induced analgesia at a dose of 10 mg/kg.Formal Name: N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetrenamide. CAS Number: 183718-77-6. Synonyms: 4-HPA, N-(4-hydroxyphenyl)-Arachidonoyl Amide. Molecular Formula: C26H37NO2. Formula Weight: 395.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2)(1:3): .25 mg/ml, PBS pH 7.2: 50 µg/ml, PBS pH 9.0: 95 µg/ml. lambdamax: 250 nm. SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1ccc(O)cc1. InChi Code: InChI=1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6-,10-9-,13-12-,16-15-. InChi Key: IJBZOOZRAXHERC-DOFZRALJSA-N.