Alisol C Monoacetate

Alisol C monoacetate is a triterpenoid that has been found in Alisma orientale and has diverse biological activities. It is active against certain antibiotic-resistant strains of S. aureus, E. faecium, E. coli, and P. aeruginosa (MICs = 2.5-5 µg/ml) but not against other antibiotic-resistant strains of S. aureus or E. coli (MICs = >256 µg/ml). Alisol C monoacetate (1-10 µM) inhibits osteoclast formation induced by calcitriol (Cay-71820) in a co-culture of primary rat osteoblasts and primary rat bone marrow cells. It reduces trabecular bone loss and serum levels of a variety of cytokines, including TNF-alpha, IL-6, and IL-1beta, in an ovariectomized rat model of osteoporosis when administered at doses of 1 and 2 mg/kg. Alisol C monoacetate (10 and 50 mg/kg) also reduces ear edema in a mouse model of delayed-type hypersensitivity.Formal Name: (8alpha,9beta,11beta,14beta,23S,24R)-23-(acetyloxy)-24,25-epoxy-11-hydroxy-dammar-13(17)-ene-3,16-dione. CAS Number: 26575-93-9. Synonyms: AC23A, Alisol C 23-acetate. Molecular Formula: C32H48O6. Formula Weight: 528.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 3 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. lambdamax: 246 nm. SMILES: C[C@@]12[C@@]3(C(C[C@@H]([C@@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)O)=C(C(C3)=O)[C@H](C)C[C@@H]([C@]5([H])C(C)(O5)C)OC(C)=O)C. InChi Code: InChI=1S/C32H48O6/c1-17(14-22(37-18(2)33)27-29(5,6)38-27)25-19-15-20(34)26-30(7)12-11-24(36)28(3,4)23(30)10-13-31(26,8)32(19,9)16-21(25)35/h17,20,22-23,26-27,34H,10-16H2,1-9H3/t17-,20+,22+,23+,26+,27-,30+,31+,32+/m1/s1. InChi Key: KOOCQNIPRJEMDH-QSKXMHMESA-N. Origin: Plant/Alisma plantago-aquatica tubers.