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Leukotriene D4
Item number: Cay20310-25
Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Cay-20210) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by gamma-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal...
| Keywords: | LTD4, 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 73836-78-9 |
| MW: | 496.7 D |
From 193.00€
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1-Oleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)
Item number: Cay62215-5
1-Oleoyl-2-hydroxy-sn-glycero-3-PA is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase....
| Keywords: | Oleoyl-sn-3-glycerophosphate, 9Z-octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, monosodium salt |
| Application: | Bioactive lipid assays |
| CAS | 325465-93-8 |
| MW: | 458.5 D |
From 43.00€
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Leukotriene C4
Item number: Cay20210-25
Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A)...
| Keywords: | LTC4, 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 72025-60-6 |
| MW: | 625.8 D |
From 193.00€
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BPR0912
Item number: Cay10678-1
BPR0912 is a cannabinoid 1 (CB1) receptor inverse agonist (IC50 = 8.5 nM for the human receptor). It is selective for CB1 over CB2 receptors (IC50 = 604.9 nM for the human receptor). In vivo, BPR0912 (10 mg/kg per day) inhibits diet-induced increases in body weight, epididymal and inguinal fat pad mass, and serum...
| Keywords: | TM38837,... |
| Application: | CB1 receptor inverse agonist |
| CAS | 1253641-65-4 |
| MW: | 617.5 D |
From 34.00€
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1,2-Dipalmitoyl-sn-glycero-3-N,N-dimethyl-PE
Item number: Cay25589-25
1,2-Dipalmitoyl-sn-glycero-3-N,N-dimethyl-PE is a form of 1,2-dipalmitoyl-sn-glycero-3-PE (1,2-DPPE, Cay-15092) that contains two methyl groups on the sn-3 moiety. In aqueous suspensions, it lowers the phase transition temperature compared with aqueous suspensions of 1,2-DPPE and...
| Keywords: | 1,2-Dipalmitoyl-sn-glycero-3-N,N-dimethyl-Phosphoethanolamine, 1,2-N,NMe2DPPE, 16:0 Dimethyl PE, hexadecanoic acid,... |
| Application: | Liposomes & monolayer formation |
| CAS | 3922-61-0 |
| MW: | 720 D |
From 114.00€
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Ganglioside GM1 (bovine) (ammonium salt)
Item number: Cay31548-1
Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane. It associates with growth factor receptors, including TrkA,...
| Keywords: | GM1, Monosialoganglioside GM1,... |
| Application: | Monosialylated gangliosides |
| CAS | 1007119-81-4 |
| MW: | 1563.9 D |
160.00€
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DSPE-PEG(2000) Cyanur
Item number: Cay37797-1
DSPE-PEG(2000) Cyanur is a PEGylated form of 1,2-distearoyl-sn-glycero-3-PE (DSPE, Cay-15095) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of micro RNA (miRNA) in vitro. LNPs containing DSPE-PEG(2000) cyanur, encapsulating let-7a miRNA, and conjugated to the Eph tyrosine kinase...
| Keywords: | 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000 Cyanur,... |
| Application: | PEGylated DSPE, LNP formation |
| CAS | 1246304-74-4 |
| MW: | 1044.2 D |
From 34.00€
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Lipid M
Item number: Cay38775-1
Lipid M is an ionizable cationic lipid (pKa = 6.75) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo. LNPs containing lipid M and encapsulating mRNA encoding influenza virus genes increase anti-influenza virus IgG titers in cynomolgus monkeys without inducing local edema,...
| Keywords: | 2-octyl-decanoic acid, 7-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2089251-57-8 |
| MW: | 710.2 D |
From 118.00€
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A17
Item number: Cay39686-100
A17 is a bile acid derivative. It reduces triglyceride accumulation induced by oleic acid (Cay-90260, Cay-24659), increases cell viability, and decreases oleic acid-induced lipid peroxidation in primary rat hepatocytes when used at concentrations of 10 and 25 µM. A17 (25 µM) reduces levels of CD36, also known as...
| Keywords: | (3alpha,5beta,7beta)-3,7-bis(formyloxy)-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-cholan-24-amide |
| Application: | Bile acid derivative |
| CAS | 2568186-47-8 |
| MW: | 533.7 D |
From 50.00€
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(±)9(10)-EpODE(gamma)
Item number: Cay39906-100
(±)9(10)-EpODE(gamma) is an oxylipin.Formal Name: (Z)-8-((2S)-3R-((Z)-oct-2-en-1-yl)oxiran-2-yl)oct-6-enoic acid. Synonyms: (±)9(10)-epoxy-6(Z),12(Z)-ODE(gamma), (±)9(10)-epoxy-cis-6,12-gamma-Octadecadienoic Acid, (±)9(10)-epoxy-gamma-Octadecadienoic Acid, FA 18:3,O. Molecular Formula: C18H30O3. Formula Weight:...
| Keywords: | (±)9(10)-epoxy-cis-6,12-gamma-Octadecadienoic Acid, (±)9(10)-epoxy-6(Z),12(Z)-ODE(gamma),... |
| Application: | Oxylipin |
| MW: | 294.4 D |
From 66.00€
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E12CA1A3
Item number: Cay40415-1
E12CA1A3 is an ionizable cationic lipid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing E12CA1A3 and encapsulating an mRNA reporter induce luciferase reporter expression in mouse bone marrow-derived dendritic cells (BMDCs)...
| Keywords: | 2-hexyl-decanoic acid, 2-[4-(dimethylamino)-1-oxobutoxy]dodecyl ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2778182-26-4 |
| MW: | 553.9 D |
From 47.00€
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(3beta,4beta,17beta)-17-(2-Pyridinylmethyl)androst-5-ene-...
Item number: Cay40438-1
(3beta,4beta,17beta)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is a sterol lipid and derivative of 5-androstenetriol (Cay-35273). It is cytotoxic to MDA-MB-231 breast, PC3 prostate, HeLa cervical, and HT-29 colon cancer cells (IC50s = 9, 52.1, 26.6, and 8 µM, respectively) but not MRC-5 fibroblasts (IC50 =...
| Keywords: | 17-(2-pyridinylmethyl)-androst-5-ene-3beta,4beta,17beta-triol |
| Application: | Sterol lipid, 5-androstenetriol derivative |
| CAS | 1393651-00-7 |
| MW: | 397.6 D |
From 43.00€
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