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(±)19(20)-EpDPA
Item number: Cay10175-500
(±)-19(20)-EpDPA is an epoxide metabolite of docosahexaenoic acid (DHA, Cay-90310, Cay-17950). It is formed from DHA by various cytochrome P450 (CYP) isoforms. In vivo, (±)-19(20)-EpDPA (100 ng/animal, i.p.) suppresses hepatic crown-like structure (hCLS) formation and liver fibrosis in wild-type, but not...
| Keywords: | (±)19,20 EDP, (±)19,20-EpDPE, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA,... |
| Application: | CYP450 metabolism studies |
| MW: | 344.5 D |
From 56.00€
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Maresin 1
Item number: Cay10878-10
Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from docosahexaenoic acid (DHA, Cay-90310, Cay-17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-alpha-induced increases in reactive oxygen species (ROS) in...
| Keywords: | 7(R)-MaR1, 7(R)-Maresin 1, 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid |
| Application: | Inflammation studies |
| CAS | 1268720-28-0 |
| MW: | 360.5 D |
From 104.00€
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12(S)-HETE-d8
Item number: Cay334570-25
12(S)-HETE-d8 is intended for use as an internal standard for the quantification of 12-HETE by GC- or LC-MS. (±)12-HETE is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 12(S)- and 12(R)-HETE are formed by 12(S)- and 12(R)-lipoxygenase-mediated oxidation of arachidonic...
| Keywords: | 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Application: | Standard |
| CAS | 84807-90-9 |
| MW: | 328.5 D |
From 238.00€
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Dihomo-gamma-Linolenic Acid
Item number: Cay90230-10
Dihomo-gamma-Linolenic Acid (DGLA, 20:3), an elongation product of gamma-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, including PGE1. In mice, DGLA supplementation...
| Keywords: | cis-8,11,14-Eicosatrienoic Acid, DGLA, gamma-Homolinolenic Acid, 8Z,11Z,14Z-eicosatrienoic acid |
| Application: | LTB4 receptor antagonist |
| CAS | 1783-84-2 |
| MW: | 306.5 D |
From 46.00€
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Myriocin
Item number: Cay63150-5
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the...
| Keywords: | ISP-1, Thermozymocidin, 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid |
| Application: | Serine palmitoyltransferase inhibitor |
| CAS | 35891-70-4 |
| MW: | 401.5 D |
From 38.00€
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alpha-Linolenic Acid
Item number: Cay90210-50
alpha-Linolenic acid (ALA) is an essential omega-3 polyunsaturated fatty acid found in plants. It is converted to the longer-chain fatty acids eicosapentaenoic (Cay-90110, Cay-90110.1, Cay-21908), docosapentaenoic (Cay-90165, Cay-21907), and docosahexaenoic acid (Cay-90310). It is also catabolized via fatty acid...
| Keywords: | ALA, C18:3 (9Z,12Z,15Z), C18:3 n-3, 9Z,12Z,15Z-octadecatrienoic acid |
| Application: | Bioactive lipid studies |
| CAS | 463-40-1 |
| MW: | 278.4 D |
From 35.00€
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Oleic Acid
Item number: Cay90260-500
Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic...
| Keywords: | cis-9-Octadecenoic acid, 9Z-octadecenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 112-80-1 |
| MW: | 282.5 D |
From 28.00€
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Fingolimod (hydrochloride)
Item number: Cay10006292-50
Fingolimod is an immune modulator, a prodrug form of the sphingosine-1-phosphate (S1P) receptor agonist FTY720 phosphate (Cay-10008639), and a derivative of myriocin (Cay-63150). It selectively inhibits calcium-dependent cytosolic phospholipase A2 (cPLA2) over calcium-independent PLA2 (iPLA2) and secretory PLA2...
| Keywords: | FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride |
| Application: | Immune Modulator |
| CAS | 162359-56-0 |
| MW: | 343.9 D |
From 84.00€
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Linoleic Acid
Item number: Cay90150-50
Linoleic acid is an essential omega-6 polyunsaturated fatty acid (PUFA). It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 µM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing...
| Keywords: | 9,12-Octadecadienoic Acid, C18:2 n-6, C18:2(9Z,12Z), Telfairic Acid, 9Z,12Z-octadecadienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 60-33-3 |
| MW: | 280.5 D |
From 28.00€
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13,14-dihydro-15-keto Prostaglandin D2
Item number: Cay12610-1
13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 (Cay-12010) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa...
| Keywords: | 13,14-dihydro-15-keto PGD2, 9alpha-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid |
| Application: | CRTH2 receptor agonist, DP2 receptor agonist |
| CAS | 59894-07-4 |
| MW: | 352.5 D |
From 175.00€
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Tafluprost
Item number: Cay10005440-25
Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Cay-10005439) and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v)...
| Keywords: | AFP-168, 15,15-difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl... |
| Application: | FP receptor agonist |
| CAS | 209860-87-7 |
| MW: | 452.5 D |
From 150.00€
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Thromboxane B2-d4
Item number: Cay319030-25
Thromboxane B2-d4 (TXB2-d4) is intended for use as an internal standard for the quantification of TXB2 (Cay-19030) by GC- or LC-MS. TXB2 is a non-enzymatically derived, stable, inactive metabolite of TXA2, which is highly unstable. Serum levels of TXB2 positively correlate with platelet COX-1 activation. Urinary...
| Keywords: | TXB2-d4, 9alpha,11,15S-trihydroxy-thromba-5Z,13E-dien-1-oic-3,3,4,4-d4 acid |
| Application: | Standard |
| CAS | 1346112-79-5 |
| MW: | 374.5 D |
From 241.00€
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