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306-O12B-3
Item number: Cay37096-10
306-O12B-3 is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of antisense oligonucleotides (ASOs). LNPs containing 306-O12B-3 localize to the liver after intravenous administration in mice. LNPs containing 306-O12B-3 in combination with other lipids...
| Keywords: | bis(2-(octyldisulfaneyl)ethyl) 3,3'-((4-methyl-11-oxo-12-oxa-15,16-dithia-4,8-diazatetracosyl)azanediyl)dipropionate |
| Application: | Cationic lipidoid, LNP formation, antisense oligonucleotide delivery |
| MW: | 974.6 D |
From 186.00€
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Cho-es-Lys
Item number: Cay37337-1
Cho-es-Lys is a cationic cholesterol derivative composed of cholesterol (Cay-9003100) conjugated to an L-lysine head group containing two primary amines (pKas = 10.48 and 9.46) via a hexanediol linker. It has been used for transfection of Cy3-pDNA in COS-7 cells. Cho-es-Lys nanocomplexes containing luciferase siRNA...
| Keywords: | CEL, L-lysine, 6-[[[(3beta)-cholest-5-en-3-yloxy]carbonyl]oxy]hexyl ester, 2,2,2-trifluoroacetate |
| Application: | Cationic cholesterol derivative w/two primary amines |
| CAS | 1356250-80-0 |
| MW: | 887.1 D |
From 45.00€
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24alpha-ethyl Cholesterol
Item number: Cay37386-10
24alpha-ethyl Cholesterol is a phytosterol that has been found in S. plebian and has diverse biological activities. It protects lard from thermal oxidation when used at concentrations of 0.02 and 0.04%. 24alpha-ethyl Cholesterol (100 µM) induces glucose uptake and lipolysis in primary rat differentiated adipocytes...
| Keywords: | beta-Sitosterol, 22,23-dihydro Stigmasterol, Cupreol, NSC 18173, NSC 49083, NSC 8096, Rhamnol, SKF 14463,... |
| Application: | Bioactive phytosterol |
| CAS | 83-46-5 |
| MW: | 414.7 D |
From 142.00€
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Ermanin
Item number: Cay37535-10
Ermanin is a methoxylated flavone that has been found in bee glue and has diverse biological activities. It increases the levels of intracellular reactive oxygen species (ROS) and decreases the levels of glutathione (GSH) in B16/F10 mouse melanoma cells and primary mouse melanocytes when used at concentrations of 8...
| Keywords: | 5,7-Dihydroxy-3,4'-dimethoxyflavone, Kaempferol 3,4'-di-O-methyl ether, NSC 31882,... |
| Application: | Bioactive methoxylated flavone |
| CAS | 20869-95-8 |
| MW: | 314.3 D |
From 54.00€
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306-O12B
Item number: Cay37549-10
306-O12B is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9...
| Keywords: | tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate |
| Application: | Ionizable cationic lipidoid, LNP formation |
| CAS | 2566523-06-4 |
| MW: | 1251.09 D |
From 157.00€
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113-O12B
Item number: Cay37671-10
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing...
| Keywords: | tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetrapropionate |
| Application: | Cationic lipidoid, LNP generation |
| CAS | 2803699-72-9 |
| MW: | 1223 D |
From 186.00€
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GK241
Item number: Cay37689-1
GK241 is a secretory phospholipase A2 (sPLA2) (Type IIA) inhibitor (IC50s = 0.143 and 0.068 µM for the human and mouse enzymes, respectively). It inhibits IL-1beta-induced production of prostaglandin E2 (PGE2, Cay-14010) in isolated rat renal mesangial cells when used at concentrations of 3 and 10 µM. GK241 also...
| Keywords: | N-(1,2-dioxohexadecyl)-L-valine |
| Application: | sPLA2 (type IIA) inhibitor |
| CAS | 1899930-93-8 |
| MW: | 369.5 D |
From 84.00€
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Cholesteryl Linoleate-d11
Item number: Cay37920-100
Cholesteryl linoleate-d11 is intended for use as an internal standard for the quantification of cholesteryl linoleate (Cay-22597) by GC- or LC-MS. Cholesteryl linoleate is a pro-atherogenic cholesterol ester. It has been found in the plasma membrane of macrophages as a component of LDL, where it undergoes oxidation...
| Keywords: | 18:2(9Z,12Z)-d11 CE, C18:2(9Z,12Z)-d11 Cholesteryl ester, CE(18:2)-d11, Cholest-5-en-3beta-yl... |
| Application: | GC-MS, LC-MS internal standard, quantification, pro-atherogenic cholesterol ester |
| MW: | 660.2 D |
From 53.00€
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Heptadecanoyl-L-carnitine (chloride)
Item number: Cay37934-1
Heptadecanoyl-L-carnitine is a long-chain acylcarnitine composed of heptadecanoic acid (Cay-19722) and L-carnitine (Cay-21489). Levels of heptadecanoyl-L-carnitine are increased in dried blood spots from neonates with propionic or methylmalonic acidemias, inborn errors of metabolism characterized by a deficiency in...
| Keywords: | C17:0 Carnitine, CAR 17:0, L-Carnitine heptadecanoyl ester, L-Heptadecanoylcarnitine,... |
| Application: | Long-chain acylcarnitine |
| CAS | 173686-69-6 |
| MW: | 450.1 D |
From 151.00€
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Eicosapentaenoic Acid-d5 ethyl ester
Item number: Cay37972-100
Eicosapentaenoic acid-d5 ethyl ester is intended for use as an internal standard for the quantification of eicosapentaenoic acid ethyl ester (Cay-10008884) by GC- or LC-MS. Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the omega-3 fatty acid EPA (Cay-90110, Cay-90110.1, Cay-21908). Dietary...
| Keywords: | EPA-d5 ethyl ester, 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic-19,19,20,20,20-d5 acid, ethyl ester |
| Application: | GC-MS, LC-MS internal standard, quantification, eicosapentaenoic acid ethyl ester |
| CAS | 2483831-19-0 |
| MW: | 335.5 D |
From 169.00€
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A12-Iso5-2DC18
Item number: Cay38586-1
A12-Iso5-2DC18 is an ionizable cationic lipidoid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing A12-Iso5-2DC18 and encapsulating mRNA encoding luciferase have been used to induce luciferase expression in HeLa cells.Formal Name:...
| Keywords: | 1-[3-(dimethylamino)propyl]-5,5-di-(8Z)-8-heptadecen-1-yl-2,5-dihydro-1H-imidazole-2-carboxylic acid, ethyl ester |
| Application: | Ionizable cationic lipidoid, LNP formation |
| CAS | 2412492-06-7 |
| MW: | 700.2 D |
From 130.00€
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1-Myristyl-2-hydroxy-sn-glycero-3-PA
Item number: Cay9001408-1
1-Myristyl-2-hydroxy-sn-glycero-3-PA (1-myristyl LPA) is an LPA derivative containing myristic acid (Cay-13351) at the sn-1 position and agonist of lysophosphatidic acid receptor 1 (LPA1) and LPA2. It increases calcium mobilization in a reporter assay using HEL 92.1.7 cells (EC50 = 37 nM).Formal Name:...
| Keywords: | 14:0 Lyso PA, 1-Myristyl LPA, 1-Myristyl-sn-glycero-3-phosphate, 1-Tetradecyl-sn-glycero-3-phosphate, LPA(14:0),... |
| Application: | LPA derivative, LPA1 and LPA2 agonist |
| MW: | 368.5 D |
From 40.00€
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