Cholesteryl Linoleate-d11

Cholesteryl linoleate-d11 is intended for use as an internal standard for the quantification of cholesteryl linoleate (Cay-22597) by GC- or LC-MS. Cholesteryl linoleate is a pro-atherogenic cholesterol ester. It has been found in the plasma membrane of macrophages as a component of LDL, where it undergoes oxidation to form cholesteryl linoleate hydroperoxides (Cay-48001). Cholesteryl linoleate levels are increased in apoB-lipoproteins and positively correlated with hepatic cholesterol levels and the number of atherosclerotic lesions in transgenic mice overexpressing human ABCA1. Lipoprotein levels of cholesteryl linoleate are increased and associated with lipid radical formation in patients with beta-thalassemia.Formal Name: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (9Z,12Z)-octadeca-9,12-dienoate-14,14,15,15,16,16,17,17,18,18,18-d11. Synonyms: 18:2(9Z,12Z)-d11 CE, C18:2(9Z,12Z)-d11 Cholesteryl ester, CE(18:2)-d11, Cholest-5-en-3beta-yl (9Z,12Z-octadecadienoate-d11), Cholesterol Linoleate-d11, Linoleic Acid cholesterol ester-d11. Molecular Formula: C45H65D11O2. Formula Weight: 660.2. Purity: >99% deuterated forms (d1-d11). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Methyl Acetate: 1 mg/ml. SMILES: C[C@]12C(C[C@@H](OC(CCCCCCC/C=C\C/C=C\C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])[2H])=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@@H](CCCC(C)C)C)[H]. InChi Code: InChI=1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1/i1D3,7D2,8D2,9D2,10D2. InChi Key: NAACPBBQTFFYQB-QEZOUDLJSA-N.