306-O12B-3

306-O12B-3 is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of antisense oligonucleotides (ASOs). LNPs containing 306-O12B-3 localize to the liver after intravenous administration in mice. LNPs containing 306-O12B-3 in combination with other lipids encapsulating ASOs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) decrease hepatic PCSK9 expression in mice. Intravenous administration of LNPs containing 306-O12B-3 and the cationic lipidoid NT1-O14B (Cay-37095) encapsulating ASOs against tau decreases tau expression and levels in mouse brain.Formal Name: bis(2-(octyldisulfaneyl)ethyl) 3,3'-((4-methyl-11-oxo-12-oxa-15,16-dithia-4,8-diazatetracosyl)azanediyl)dipropionate. CAS Number: 2982842-90-8. Molecular Formula: C46H91N3O6S6. Formula Weight: 974.6. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Ethanol: 10 mg/ml. SMILES: O=C(OCCSSCCCCCCCC)CCN(CCCN(C)CCCNCCC(OCCSSCCCCCCCC)=O)CCC(OCCSSCCCCCCCC)=O. InChi Code: InChI=1S/C46H91N3O6S6/c1-5-8-11-14-17-20-38-56-59-41-35-53-44(50)25-29-47-28-23-30-48(4)31-24-32-49(33-26-45(51)54-36-42-60-57-39-21-18-15-12-9-6-2)34-27-46(52)55-37-43-61-58-40-22-19-16-13-10-7-3/h47H,5-43H2,1-4H3. InChi Key: JGLIHHAQZDZCLQ-UHFFFAOYSA-N.