Lipids

Lipids are small, organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids. Lipids are the main structural component of biological membranes of all cells. As such, bacterial lipid structures and glycolipids can serve as pathogen-associated molecular patterns (PAMPs) and are recognized by the human immune system. Various lipids and lipid complexes of bacterial origin are therefore used as immunostimulants.

Lipids are small,  organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids.... read more »
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Lipids

Lipids are small, organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids. Lipids are the main structural component of biological membranes of all cells. As such, bacterial lipid structures and glycolipids can serve as pathogen-associated molecular patterns (PAMPs) and are recognized by the human immune system. Various lipids and lipid complexes of bacterial origin are therefore used as immunostimulants.

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Linoleic Acid glycidyl ester
Linoleic Acid glycidyl ester

Item number: Cay36840-5

Linoleic acid glycidyl ester is an esterified form of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) containing a glycidyl group. It is hydrolyzed in vivo to glycidol, which is carcinogenic in rats. Linoleic acid glycidyl ester has been found in commercial edible oils and infant formulas.Formal Name:...
Keywords: C18:2 glycidyl ester, C18:2-GE, Glycidyl Linoleate, Glycidyl Octadecadienoate, 9Z,12Z-octadecadienoic acid,...
Application: Linoleic acid esterified form
CAS 24305-63-3
MW: 336.5 D
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1-1(Z)-Octadecenyl-2-Arachidonoyl-sn-glycero-3-PE
1-1(Z)-Octadecenyl-2-Arachidonoyl-sn-glycero-3-PE

Item number: Cay37137-5

1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) at the sn-1 and sn-2 positions, respectively. It has been found in chicken breast meat.Formal Name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid,...
Keywords: 1-1(Z)-Octadecenyl-2-Arachidonoyl-sn-glycero-3-Phosphatidylethanolamine,...
Application: Plasmalogen
CAS 144371-69-7
MW: 752.1 D
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Trehalose 6,6'-Dibehenate
Trehalose 6,6'-Dibehenate

Item number: Cay37911-1

Trehalose 6,6'-dibehenate (TDB) is a synthetic glycolipid and derivative of trehalose-6,6' dimycolate (TDM), also known as mycobacterial cord factor. It binds to a fusion protein of mouse macrophage-inducible C-type lectin (Mincle) and human IgG1 Fc in a cell-free assay when used at a concentration of 10 µg/ml. TDB...
Keywords: 22:0 Trehalose, TDB, Trehalose Dibehenate, 6-docosanoate 6-O-(1-oxodocosyl)-alpha-D-glucopyranosyl alpha-D-glucopyranoside
Application: Synthetic glycolipid, trehalose-6,6' dimycolate (TDM) derivative
CAS 66758-35-8
MW: 987.4 D
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1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC
1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC

Item number: Cay38430-1

1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC is a phospholipid-porphyrin conjugate that is composed of phosphatidylcholine containing palmitic acid (Cay-10006627) at the sn-1 position and the photosensitizer pyropheophorbide a (Cay-21371) at the sn-2 position. Lipid nanoparticles (LNPs) containing...
Keywords: 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphatidylcholine, 1-Palmitoyl-2-Pyropheophorbide...
Application: Phospholipid-porphyrin conjugate
CAS 1287795-07-6
MW: 1012.3 D
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Lauric Acid ethyl ester
Lauric Acid ethyl ester

Item number: Cay10008203-1

Lauric acid is a common 12-carbon saturated fatty acid plentiful in coconut and other nut oils. Saturated fatty acids induce the expression of cyclooxygenase-2, an effect that is significant at 25 µM in RAW 264.7 cells, with lauric acid being the most potent of the C:8-18 fatty acids. Lauric acid ethyl ester is a...
Keywords: Ethyl dodecanoate, Ethyl laurate, NSC 83467, NSC 8912, dodecanoic acid, ethyl ester
Application: Bioactive lipid assays
CAS 106-33-2
MW: 228.4 D
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Lipid 5
Lipid 5

Item number: Cay34372-10

Lipid 5 is an ionizable cationic amino lipid (pKa = 6.56). It has been used in the synthesis of lipid nanoparticles (LNPs) for mRNA delivery and protein expression in rodents and non-human primates.Formal Name: 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-octanoic acid, 1-octylnonyl ester. CAS Number:...
Keywords: 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-octanoic acid, 1-octylnonyl ester
Application: Cationic amino lipid, lipid nanoparticle mRNA delivery
CAS 2089251-33-0
MW: 710.2 D
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1-Oleoyl-2-Linoleoyl-rac-glycerol
1-Oleoyl-2-Linoleoyl-rac-glycerol

Item number: Cay37241-1

1-Oleoyl-2-linoleoyl-rac-glycerol is a diacylglycerol that contains oleic acid (Cay-90260, Cay-24659) and linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) at the sn-1 and sn-2 positions, respectively. It has been found in raw and dry-cured Iberian ham.Formal Name: 9Z,12Z-octadecadienoic acid,...
Keywords: 1-Olein-2-Linolein-rac-glycerol, DG(18:1/0:0/18:2), 9Z,12Z-octadecadienoic acid,...
Application: Diacylglycerol
CAS 106292-55-1
MW: 619 D
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DSPE-PEG(2000)-NHS
DSPE-PEG(2000)-NHS

Item number: Cay37275-100

DSPE-PEG(2000)-NHS is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE, Cay-15095). It has been used in the generation of micelles and in combination with other lipids in the formation of liposomes. DSPE-PEG(2000)-NHS-containing liposomes localize to the liver and tumor after intravenous administration...
Keywords: (2R)-3-((((14-((2,5-dioxopyrrolidin-1-yl)oxy)-4,14-dioxo-5,8,11-trioxa-3-azatetradecyl)oxy)(hydroxy)phosphoryl)oxy)propane...
Application: DSPE PEGylated derivative
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98N12-5
98N12-5

Item number: Cay37651-5

98N12-5 is an ionizable cationic lipid. It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol...
Keywords: ND98, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-4,7,10,13-tetraazahexadecanediamide
Application: Ionizable cationic lipid, LNP formation
CAS 917572-74-8
MW: 1343.2 D
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DMHCA
DMHCA

Item number: Cay37712-1

DMHCA is a liver X receptor (LXR) agonist. It activates LXRalpha and LXRbeta in CV-1 cells expressing the human receptors in reporter assays (EC50 = 2 µM for both). DMHCA also inhibits ?24-dehydrocholesterol reductase (DHCR24, IC50 = 0.7 nM). It does not induce steatosis or increase liver triglyceride levels...
Keywords: Dimethyl-HCA, N,N-Dimethyl-3beta-hydroxycholenamide, (3beta)-3-hydroxy-N,N-dimethyl-chol-5-en-24-amide
Application: LXR agonist
CAS 79066-03-8
MW: 401.6 D
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Bufalin
Bufalin

Item number: AG-CN2-0533-M010

Isolated from venenum bufonis. Soluble in DMSO (5mg/ml), ethanol (15mg/ml) or DMF (20mg/ml). Bufalin is a cardiotonic steroid with anaesthetic, blood pressure stimulatory and respiratory activities. It is a potent Na+/K+-ATPase transporter inhibitor (Kd = 42, 45, and 40nM for the alpha1, alpha2, and alpha3 subunits,...
Keywords: (3beta,5beta)-3,14-Dihydroxy-bufa-20,22-dienolide, NSC 89595, BRN 5141601
Application: Cardiotonic steroid, potent Na+/K+-ATPase transporter inhibitor
CAS 465-21-4
MW: 386.5 D
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Tetradecyl Phosphonate
Tetradecyl Phosphonate

Item number: Cay10007565-1

Lysophosphatidic acid (LPA) is a lipid signalling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D, also known as autotaxin (ATX). LPA signals through four different G protein-coupled receptors, LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23. Activation of peroxisome...
Keywords: tetradecylphosphonic acid
Application: LPA receptor antagonist
CAS 4671-75-4
MW: 278.4 D
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324 from 345 pages