8-iso Prostaglandin E2-d4

8-iso Prostaglandin E2-d4 (8-iso PGE2-d4) is intended for use as an internal standard for the quantification of 8-iso PGE2 (Cay-14350) by GC- or LC-mass spectrometry. 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.Formal Name: 9-oxo-11alpha,15S-dihydroxy-(8beta)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. Synonyms: 8-epi PGE2-d4, 8-iso PGE2-d4. Molecular Formula: C20H28D4O5. Formula Weight: 356.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >5 mg/ml. SMILES: CCCCCC(O)/C=C/[C@H]1C(O)CC(=O)[C@H]1C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,19+/m0/s1/i5D2,8D2. InChi Key: XEYBRNLFEZDVAW-APSMZUSFSA-N.