8-iso-15-keto Prostaglandin F2beta

8-iso Prostaglandin F2beta (8-iso PGF2beta) is an isomer of PGF2alpha of non-enzymatic origin. It is one of 64 possible isomers of PGF2alpha which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2beta exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2beta moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2alpha. 8-iso-15-keto PGF2beta is a potential metabolite of 8-iso PGF2beta via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2beta.Formal Name: 9beta,11alpha-dihydroxy-15-oxo-(8beta)-prosta-5Z,13E-dien-1-oic acid. CAS Number: 1621482-36-7. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 234 nm. SMILES: O[C@@H]1C[C@@H](O)[C@@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/C(CCCCC)=O. InChi Code: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-19,22-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17+,18+,19+/m0/s1. InChi Key: LOLJEILMPWPILA-WZDCOHRSSA-N.