6(S)-Lipoxin A4

6(S)-Lipoxin A4 (6(S)-LXA4) is an isomer of the trihydroxy fatty acid LXA4 (Cay-90410). It is formed from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12- or 15-LO, with a leukotriene A4 (LTA4) intermediate, or by 15-LO followed by 5-LO, with 15(S)-HETE (Cay-34720) and 5(S)-Hp-15(S)-HETE intermediates. The generation of 6(S)-LXA4 and LXA4 typically requires transcellular metabolism of arachidonic acid. For example, LTA4 synthesized in neutrophils by 5-LO is metabolized to LXA4 in platelets by 12-LO. 6(S)-LXA4 has been detected in co-incubations of human polymorphonuclear leukocytes (PMNs) and platelets.Formal Name: 5S,6S,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid. CAS Number: 94292-80-5. Synonyms: 5(S),6(S)-Lipoxin A4, 6-epi-Lipoxin A4, 6(S)-LXA4, 5(S),6(S),15(S)-TriHETE. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 302 nm. SMILES: CCCCCCC(O)\C=C\C=C/C=C\C=C/C(O)C(O)CCCC(=O)O. InChi Code: InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18-,19-/m0/s1. InChi Key: IXAQOQZEOGMIQS-UZDWIPAXSA-N.