5-OxoETE Receptor Blocking Peptide

To be used in conjunction with Cayman's 5-OxoETE Receptor Polyclonal Antibody (Cay-100025) to block protein-antibody complex formation during immunochemical analysis of 5-OxoETE. The 5-OxoETE receptor recognizes eicosatetraenoic acids and polyunsaturated fatty acids including 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE), which is the most potent ligand. 5-OxoETE is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR). The receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium. Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response. In addition, the protein can also be detected in tissues such as kidney and liver.Synonyms: R527, TG1019. Amino Acids: human 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) receptor C-terminal amino acids 408-423. Formulation: (Request formulation change), 200 µg of peptide. Storage Buffer: 200 µl TBS, pH 7.4, with 0.1% BSA and 0.02% sodium azide.