(±)5-HETE lactone

(±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone is an inhibitor of 5-lipoxygenase from rat basophilic leukemia cells with an IC50 of 27 µM. The lactone is several times more potent than the linear (±)5-HETE.Formal Name: tetrahydro-6-(1E,3Z,6Z,9Z)-1,3,6,9-pentadecatetraen-1-yl-2H-pyran-2-one. CAS Number: 81517-87-5. Synonyms: (±)5-Hydroxyeicosatetraenoic Acid lactone. Molecular Formula: C20H30O2. Formula Weight: 302.5. Purity: >98%. Formulation: (Request formulation change), A solution in acetonitrile. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS pH 7.2: 1 mg/ml. lambdamax: 236 nm. SMILES: CCCCC/C=C\C/C=C\C/C=C\C=C/C1CCCC(=O)O1. InChi Code: InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(21)22-19/h6-7,9-10,12-14,16,19H,2-5,8,11,15,17-18H2,1H3/b7-6-,10-9-,13-12-,16-14+. InChi Key: QZMAEYDIHWEEAF-XTDASVJISA-N.