Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009984-10 10 µg -

3 - 10 business days*

Cay10009984-25 25 µg -

3 - 10 business days*

Cay10009984-50 50 µg -

3 - 10 business days*

5(6)-EET-d11 is intended for use as an internal standard for the quantification of (±)5(6)-EET... more
Product information "(±)5(6)-EET-d11"
5(6)-EET-d11 is intended for use as an internal standard for the quantification of (±)5(6)-EET (Cay-50211) by GC- or LC-MS. 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 µM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 µM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (±)5(6)-EET-d11 is provided as a mixture of the free acid and lactone.
Keywords: (±)5,6-EET-d11, (±)5(6)-epoxy-8Z,11Z,14Z-eicosatrienoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid
Supplier: Cayman Chemical
Supplier-Nr: 10009984-10


Application: Standard
MW: 331.5 D
Formula: C20H21D11O3
Purity: >99% deuterated forms (d1-d11)
Format: Solution

Database Information

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, EUH066
P Phrases: P210, P240, P241, P242, P243, P261, P264, P271, P280, P312, P303+P361+P353, P304+P340, P305+P351+P338, P337+P313, P370+P378, P405, P403+P233, P403+P235, P501
Our products are for laboratory research use only: Not for administration to humans!
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