(±)5(6)-DiHETE lactone

Eicosapentaenoic acid (EPA, Cay-90110) is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE (Cay-10467) is a possible metabolite produced from EPA following epoxidation of the alpha-5 double bond. (±)5(6)-DiHETE lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHETE. While its biological activity is unknown, the selective capacity of (±)5(6)-DiHETE to form this lactone can be utilized to specifically quantify (±)5(6)-DiHETE in biological samples.Formal Name: (±)-5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid 1,5-lactone. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >90%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C[C@@H](O)[C@H]1CCCC(O1)=O. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18(21)19-16-14-17-20(22)23-19/h3-4,6-7,9-10,12-13,18-19,21H,2,5,8,11,14-17H2,1H3/b4-3-,7-6-,10-9-,13-12-/t18-,19-/m1/s1. InChi Key: HMMBXEDQZSAPEQ-ZGATWMQVSA-N.