(±)5(6)-DiHET lactone

5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME (Cay-80210).Formal Name: tetrahydro-6-[(3Z,6Z,9Z)-1-hydroxy-3,6,9-pentadecatrien-1-yl]-2H-pyran-2-one. CAS Number: 213126-92-2. Synonyms: (±)5,6-DiHETrE lactone. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS pH 7.2: 1 mg/ml. SMILES: O=C(O1)CCC[C@@H]1[C@H](O)C/C=C\C/C=C\C/C=C\CCCCC. InChi Code: InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18(21)19-16-14-17-20(22)23-19/h6-7,9-10,12-13,18-19,21H,2-5,8,11,14-17H2,1H3/b7-6-,10-9-,13-12-/t18-,19-/m1/s1. InChi Key: FVXUUVSFGPLNBJ-GMKBZGQBSA-N.