4-hydroxy Diclofenac

4-hydroxy Diclofenac is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor diclofenac (Cay-70680, Cay-22983). It is formed from diclofenac by the cytochrome P450 (CYP) isoform CYP2C9 in human liver microsomes. 4-hydroxy Diclofenac inhibits COX activity (IC50 = 32 nM) and reduces prostaglandin E2 (PGE2, Cay-14010) production (IC50 = 17 nM) in isolated human rheumatoid synovial cells.Formal Name: 2-[(2,6-dichloro-4'-hydroxyphenyl)amino]-benzeneacetic acid. CAS Number: 64118-84-9. Molecular Formula: C14H11Cl2NO3. Formula Weight: 312.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 271 nm. SMILES: OC(=O)Cc1ccccc1Nc1c(Cl)cc(O)cc1Cl. InChi Code: InChI=1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20). InChi Key: KGVXVPRLBMWZLG-UHFFFAOYSA-N.