4-Biphenylacetic Acid

4-Biphenylacetic acid is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of the prodrug fenbufen (Cay-28851). It inhibits prostaglandin E2 (PGE2, Cay-14010) synthesis in a cell-free assay (IC50 = 3.2 µM). In vivo, 4-biphenylacetic acid (2 mg/kg) suppresses UV-induced erythema in guinea pigs. 4-Biphenylacetic acid (16 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It decreases phenylquinone-induced writhing in mice (ED50 = 9.9 mg/kg).Formal Name: [1,1'-biphenyl]-4-acetic acid. CAS Number: 5728-52-9. Synonyms: p-Biphenylacetic Acid, Cl-83544, Felbinac, LY601017, NSC 16284. Molecular Formula: C14H12O2. Formula Weight: 212.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, Methanol: Slightly soluble. SMILES: OC(CC1=CC=C(C2=CC=CC=C2)C=C1)=O. InChi Code: InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16). InChi Key: QRZAKQDHEVVFRX-UHFFFAOYSA-N.