306-N16B

306-N16B is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-N16B and encapsulating an mRNA reporter accumulate specifically in the mouse lung primarily in lung endothelial cells. LNPs containing both 306-N16B and 306-O12B (Cay-37549) and encapsulating mRNA encoding tuberous sclerosis complex 2 (Tsc2), a tumor suppressor, reduce tumor growth in a mouse model of pulmonary lymphangioleiomyomatosis (LAM) induced by intravenous injection of Tsc2-null kidney-derived epithelial tumor cells (TTJ cells).Formal Name: 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfaneyl)ethyl)propanamide). CAS Number: 2803699-70-7. Molecular Formula: C75H151N7O4S8. Formula Weight: 1471.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble, Methanol: Soluble. SMILES: CN(CCCN(CCC(NCCSSCCCCCCCCCCCC)=O)CCC(NCCSSCCCCCCCCCCCC)=O)CCCN(CCC(NCCSSCCCCCCCCCCCC)=O)CCC(NCCSSCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C75H151N7O4S8/c1-6-10-14-18-22-26-30-34-38-42-64-87-91-68-52-76-72(83)48-60-81(61-49-73(84)77-53-69-92-88-65-43-39-35-31-27-23-19-15-11-7-2)58-46-56-80(5)57-47-59-82(62-50-74(85)78-54-70-93-89-66-44-40-36-32-28-24-20-16-12-8-3)63-51-75(86)79-55-71-94-90-67-45-41-37-33-29-25-21-17-13-9-4/h6-71H2,1-5H3,(H,76,83)(H,77,84)(H,78,85)(H,79,86). InChi Key: VXYBSHYDQFZZLQ-UHFFFAOYSA-N.