3-methoxy Limaprost

Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity, however there are no published studies of the pharmacological properties of 3-methoxy limaprost.Formal Name: 3-methoxy-11alpha,15S-dihydroxy-17S,20-dimethyl-9-oxo-prosta-13E-en-1-oic acid. CAS Number: 1224443-96-2. Synonyms: 3-methoxy-2,3-dihydro-Limaprost, 3-methoxy-17alpha,20-dimethyl-Delta2-Prostaglandin E1. Molecular Formula: C23H40O6. Formula Weight: 412.6. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS(pH 7.2): 1 mg/ml. SMILES: O[C@@H]([C@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H]1CCCCC(OC)CC(O)=O)CC1=O. InChi Code: InChI=1S/C23H40O6/c1-4-5-8-16(2)13-17(24)11-12-20-19(21(25)15-22(20)26)10-7-6-9-18(29-3)14-23(27)28/h11-12,16-20,22,24,26H,4-10,13-15H2,1-3H3,(H,27,28)/b12-11+/t16-,17+,18?,19+,20+,22+/m0/s1. InChi Key: CQMVTHTYLSWGRI-HMHRGJHKSA-N.