Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
20-ethyl Prostaglandin F2alpha (20-ethyl PGF2alpha) is an analog of PGF2alpha in which the... more
Product information "20-ethyl Prostaglandin F2alpha"
20-ethyl Prostaglandin F2alpha (20-ethyl PGF2alpha) is an analog of PGF2alpha in which the omega-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone. Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2alpha retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2alpha increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2alpha (50 nM). In vivo effects may be prolonged using 20-ethyl PGF2alpha, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2alpha as a substrate is only 35% of the activity observed with PGF2alpha.Formal Name: 9alpha,11alpha,15S-trihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid. CAS Number: 36950-85-3. Synonyms: ICI 74205, 20-ethyl PGF2alpha. Molecular Formula: C22H38O5. Formula Weight: 382.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 33 mg/ml, DMSO: 14 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCCCC. InChi Code: InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,14-15,17-21,23-25H,2-5,7-8,10-13,16H2,1H3,(H,26,27)/b9-6-,15-14+/t17-,18+,19+,20-,21+/m0/s1. InChi Key: XSDVSOQSNGGUFY-GWSKAPOCSA-N.
Keywords: | 20-ethyl PGF2alpha, ICI 74205, 9alpha,11alpha,15S-trihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 16940 |
Properties
Application: | Bioactive lipid assays |
MW: | 382.5 D |
Formula: | C22H38O5 |
Purity: | >98% |
Format: | Solution |
Database Information
CAS : | 36950-85-3| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H225, H303, H319, H336, H360 |
P Phrases: | P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed