20-ethyl Prostaglandin E2

20-ethyl Prostaglandin E2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14940-1 1 mg -

6 - 10 business days*

64.00€
Cay14940-5 5 mg -

6 - 10 business days*

288.00€
Cay14940-10 10 mg -

6 - 10 business days*

510.00€
 
20-ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of PGE2 in which the omega-chain has been... more
Product information "20-ethyl Prostaglandin E2"
20-ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of PGE2 in which the omega-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication. Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGE2 retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency relative to unoprostone. However, ligand binding assays of this analog with respect to EP or other prostanoid receptors have not been published. E-type prostaglandins have been widely reported to have inflammatory, cytoprotective, and a variety of other effects. Formal Name: 9-oxo-11alpha,15S-dihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid. CAS Number: 37492-24-3. Synonyms: 20-ethyl PGE2. Molecular Formula: C22H36O5. Formula Weight: 380.5. Purity: >97%. Formulation: A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 125 µg/ml. SMILES: CCCCCCC[C@H](O)/C=C/[C@H]([C@H]1C/C=C\CCCC(O)=O)[C@H](O)CC1=O. InChi Code: InChI=1S/C22H36O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,14-15,17-19,21,23,25H,2-5,7-8,10-13,16H2,1H3,(H,26,27)/b9-6-,15-14+/t17-,18+,19+,21+/m0/s1. InChi Key: NXMMZTNQIJBMBC-QKIVIXBWSA-N.
Keywords: 20-ethyl PGE2, 9-oxo-11alpha,15S-dihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 14940

Properties

Application: Bioactive lipid assays
MW: 380.5 D
Formula: C22H36O5
Purity: >97%
Format: Solution

Database Information

CAS : 37492-24-3| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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