20-carboxy Arachidonic Acid

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This omega-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor alpha (PPARalpha) (Kd = 0.87 ± 0.12 µM) and PPARgamma (Kd = 1.7 ± 0.5 µM), and is a dual activator of PPARalpha and PPARgamma in a transiently transfected COS-7 cell reporter system.Formal Name: 5Z,8Z,11Z,14Z-eicosatetraenedioic acid. CAS Number: 79551-84-1. Synonyms: 20-carboxy AA, 20-COOH-AA, FA 20:4,O2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 1.5 mg/ml, DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml. SMILES: OC(=O)CCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H30O4/c21-19(22)17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(23)24/h1,3-4,6-7,9-10,12H,2,5,8,11,13-18H2,(H,21,22)(H,23,24)/b3-1-,6-4-,9-7-,12-10-. InChi Key: BGOJKUCHTMYINI-DTLRTWKJSA-N.