(±)19(20)-EpDPA

(±)-19(20)-EpDPA is an epoxide metabolite of docosahexaenoic acid (DHA, Cay-90310, Cay-17950). It is formed from DHA by various cytochrome P450 (CYP) isoforms. In vivo, (±)-19(20)-EpDPA (100 ng/animal, i.p.) suppresses hepatic crown-like structure (hCLS) formation and liver fibrosis in wild-type, but not GPR120-deficient, mice in a model of non-alcoholic steatohepatitis (NASH) induced by high-fat diet and carbon tetrachloride (CCl4). Intraplantar administration of (±)-19(20)-EpDPA induces acute mechanical hyperalgesia in mice, an effect that can be blocked by the transient receptor potential ankyrin 1 (TRPA1) inhibitor A-967079 (Cay-15207).Formal Name: (±)19,20-epoxy-4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid. Synonyms: (±)19,20 EDP, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA, (±)19,20-EpDPE. Molecular Formula: C22H32O3. Formula Weight: 344.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CC[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H32O3/c1-2-20-21(25-20)18-16-14-12-10-8-6-4-3-5-7-9-11-13-15-17-19-22(23)24/h3-4,7-10,13-16,20-21H,2,5-6,11-12,17-19H2,1H3,(H,23,24)/b4-3-,9-7-,10-8-,15-13-,16-14-/t20-,21+/m1/s1. InChi Key: OSXOPUBJJDUAOJ-MWEXLPNRSA-N.