17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1alpha

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1alpha
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15895-1 1 mg -

6 - 10 business days*

64.00€
Cay15895-5 5 mg -

6 - 10 business days*

288.00€
Cay15895-10 10 mg -

6 - 10 business days*

510.00€
 
A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2alpha derivatives have been... more
Product information "17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1alpha"
A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2alpha derivatives have been approved for the treatment of glaucoma. These "ring" prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1alpha (17-TFM-PGF1alpha) is a typical "ring" analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1alpha is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the "ring" series of analogs, this modification has little impact on FP receptor binding. As an ocular hypotensive agent, it is expected that 17-TFM-PGF1alpha would act very much like the free acid of latanoprost. Formal Name: 9alpha,11alpha,15S-trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prostan-1-oic acid. CAS Number: 1027401-98-4. Synonyms: 17-TFM-PGF1alpha. Molecular Formula: C24H35F3O5. Formula Weight: 460.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC(C(F)(F)F)=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C24H35F3O5/c25-24(26,27)17-7-5-6-16(14-17)10-11-18(28)12-13-20-19(21(29)15-22(20)30)8-3-1-2-4-9-23(31)32/h5-7,14,18-22,28-30H,1-4,8-13,15H2,(H,31,32)/t18-,19+,20+,21-,22+/m0/s1. InChi Key: DSVAWVBHUBDAPY-AHJNKEMKSA-N.
Keywords: 17-TFM-PGF1alpha, 9alpha,11alpha,15S-trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prostan-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 15895

Properties

Application: Bioactive lipid assays
MW: 460.5 D
Formula: C24H35F3O5
Purity: >98%
Format: Solution

Database Information

CAS : 1027401-98-4| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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