17(R,S)-Benzo-Resolvin D1

17(R,S)-Benzo-resolvin D1 (benzo-RvD1) is a derivative of the specialized pro-resolving mediator (SPM) RvD1 (Cay-10012554). It reduces PDGF-BB-induced cytoskeletal changes in, and PDGF-induced migration of, isolated human vascular smooth muscle cells (VSMCs) when used at concentrations of 10 and 100 nM. Benzo-RvD1 (10 nM) inhibits p65 nuclear translocation in human umbilical vein endothelial cells (HUVECs). It also increases RAW 264.7 phagocytosis of S. aureus and zymosan particles.Formal Name: (4Z,7S,8R,9E)-7,8-dihydroxy-10-(2-((Z)-1-hydroxyhex-3-en-1-yl)phenyl)deca-4,9-dienoic acid. Synonyms: Benzo-RvD1, 17(R,S)-Benzo-RvD1. Molecular Formula: C22H30O5. Formula Weight: 374.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 1 mg/ml. lambdamax: 250 nm. SMILES: OC(C/C=C\CC)C1=CC=CC=C1/C=C/[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O. InChi Code: InChI=1S/C22H30O5/c1-2-3-5-12-19(23)18-11-9-8-10-17(18)15-16-21(25)20(24)13-6-4-7-14-22(26)27/h3-6,8-11,15-16,19-21,23-25H,2,7,12-14H2,1H3,(H,26,27)/b5-3-,6-4-,16-15+/t19?,20-,21+/m0/s1. InChi Key: JSDYDMBYGJRHPY-JTUFWJBCSA-N.