17-phenyl trinor Prostaglandin F2alpha ethyl amide-d4

17-phenyl trinor Prostaglandin F2alpha ethyl amide-d4 is intended for use as an internal standard for the quantification of 17-phenyl trinor prostaglandin F2alpha ethyl amide (Cay-16820) by GC- or LC-MS. 17-phenyl trinor Prostaglandin F2alpha ethyl amide (17-phenyl trinor PGF2alpha ethyl amide) is an F-series prostaglandin derivative and an agonist of FP receptors. It induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM). Ocular administration of 17-phenyl trinor PGF2alpha ethyl amide (0.03% w/v) reduces intraocular eye pressure (IOP) in normotensive dogs and ocular hypertensive monkeys. Formulations containing 17-phenyl trinor PGF2alpha ethyl amide have been used in the treatment of open angle glaucoma, ocular hypertension, and eyelash hypotrichosis.Formal Name: N-ethyl-9alpha,11alpha,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-amide-3,3,4,4-d4. Synonyms: Bimatoprost-d4, 15(S)-Bimatoprost-d4, 17-phenyl trinor PGF2alpha ethyl amide-d4. Molecular Formula: C25H33D4NO4. Formula Weight: 419.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 0.3 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(NCC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1/i4D2,9D2. InChi Key: AQOKCDNYWBIDND-BJZNXRQDSA-N.