17,20-dimethyl Prostaglandin F1alpha

17,20-dimethyl Prostaglandin F1alpha (17,20-dimethyl PGF1alpha) is an analog of the limaprost family with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an analog of PGE1 which is orally active in both rats and guinea pigs. The additional methyl groups in the lower side chain confer a 10-1,000 fold increase in potency over the parent compound. 17,20-dimethyl PGF1alpha has lower side chain modifications identical to limaprost. There are no published reports describing the pharmacology of 17,20-dimethyl PGF1alpha.Formal Name: 9alpha,11alpha,15S-trihydroxy-17S,20-dimethyl-prost-13E-en-1-oic acid. Synonyms: 17,20-dimethyl PGF1alpha. Molecular Formula: C22H40O5. Formula Weight: 384.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >30 mg/ml, DMSO: >130 mg/ml, Ethanol: >50 mg/ml, PBS (pH 7.2): >2 mg/ml. SMILES: O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H](O)C1. InChi Code: InChI=1S/C22H40O5/c1-3-4-9-16(2)14-17(23)12-13-19-18(20(24)15-21(19)25)10-7-5-6-8-11-22(26)27/h12-13,16-21,23-25H,3-11,14-15H2,1-2H3,(H,26,27)/b13-12+/t16-,17+,18+,19+,20-,21+/m0/s1. InChi Key: GBYMYPWDCSUFAK-SXCZBBCHSA-N.