16(R)-AFP 07 (free acid)

16(R)-AFP 07 (free acid)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10991-500 500 µg -

1 - 10 business days

Cay10991-1 1 mg -

1 - 10 business days

Cay10991-5 5 mg -

1 - 10 business days

Prostaglandin I2 is an unstable prostanoid which, through the 'I prostanoid' (IP) receptor,... more
Product information "16(R)-AFP 07 (free acid)"
Prostaglandin I2 is an unstable prostanoid which, through the 'I prostanoid' (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.
Keywords: 5Z-[3aR,3-difluorohexahydro-5R-hydroxy-4R-[3R-hydroxy-4S-methyl-1E-nonen-6aS-ynyl]-2Hcyclopenta[b]furan-2-ylidene]-pentanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10991-1


Application: IP receptor agonist
MW: 412.5 D
Formula: C22H30F2O5
Purity: >98%
Format: Solution

Database Information

CAS : 773825-80-2| Search using CAS

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, EUH066
P Phrases: P210, P240, P241, P242, P243, P261, P264, P271, P280, P312, P303+P361+P353, P304+P340, P305+P351+P338, P337+P313, P370+P378, P405, P403+P233, P403+P235, P501
Our products are for laboratory research use only: Not for administration to humans!
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