16-phenoxy tetranor Prostaglandin F2alpha methyl amide

Prostaglandin F2alpha (PGF2alpha) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2alpha are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor PGF2alpha is a metabolically stable form of PGF2alpha containing a 16-phenoxy group at the omega-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2alpha. 16-phenoxy tetranor PGF2alpha methyl amide is a lipophilic analog of 16-phenoxy tetranor PGF2alpha. Methyl amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.Formal Name: 9alpha,11alpha,15R-trihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, methyl amide. Synonyms: 16-phenoxy tetranor PGF2alpha methyl amide. Molecular Formula: C23H33NO5. Formula Weight: 403.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): .5 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(NC)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C23H33NO5/c1-24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-29-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-22,25-27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2-,14-13+/t17-,19-,20-,21+,22-/m1/s1. InChi Key: RVIFBIOAPWHJAL-CNAXQHPCSA-N.