16,16-dimethyl Prostaglandin A1

16,16-dimethyl Prostaglandin A1 (16,16-dimethyl PGA1) is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 µg/ml.Formal Name: 15R-hydroxy-16,16-dimethyl-9-oxo-prosta-10,13E-dien-1-oic acid. CAS Number: 41692-24-4. Synonyms: 16,16-dimethyl PGA1. Molecular Formula: C22H36O4. Formula Weight: 364.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >75 mg/ml, DMSO: >50 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >2.4 mg/ml. lambdamax: 216 nm. SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)C=C1. InChi Code: InChI=1S/C22H36O4/c1-4-5-16-22(2,3)20(24)15-13-17-12-14-19(23)18(17)10-8-6-7-9-11-21(25)26/h12-15,17-18,20,24H,4-11,16H2,1-3H3,(H,25,26)/b15-13+/t17-,18-,20-/m1/s1. InChi Key: CTQQHQGBBMYJPT-DZFVFWAGSA-N.