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Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM. 15(R)-Iloprost is the "unnatural" or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost.Formal Name: (5E)-5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-pentanoic acid. CAS Number: 85026-51-3. Molecular Formula: C22H32O4. Formula Weight: 360.5. Purity: >97%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: O[C@H]1[C@H](/C=C/[C@H](O)C(C)CC#CC)[C@@H](C/C(C2)=C/CCCC(O)=O)[C@@H]2C1. InChi Code: InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20-,21+/m0/s1. InChi Key: HIFJCPQKFCZDDL-GAGQTBDJSA-N.
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