15(R)-15-methyl Prostaglandin E2

15(R)-15-methyl Prostaglandin E2 (15(R)-15-methyl PGE2) is a prodrug for the potent PGE2 (Cay-14010) analog 15(S)-15-methyl PGE2 (Cay-14730). Acid-catalyzed epimerization in the stomach produces the 15(S)-hydroxy compound which is biologically active. Oral administration of 15(R)-15-methyl PGE2 to dogs or rats at 10-300 µg/kg results in a dose-dependent inhibition of gastric acid secretion and an increase in the rate of duodenal bicarbonate secretion.Formal Name: 9-oxo-11alpha,15R-dihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid. CAS Number: 55028-70-1. Synonyms: Arbaprostil, 15(R)-15-methyl PGE2. Molecular Formula: C21H34O5. Formula Weight: 366.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: >5 mg/ml. SMILES: O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@](C)(O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-17,19,23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,19-,21-/m1/s1. InChi Key: XSGQFHNPNWBVPT-VFXMVCAWSA-N.