15-keto Prostaglandin A1

Prostaglandin A1 (PGA1) (Cay-10010) was first isolated as a dehydration product of the PGE1 (Cay-13010) compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 µM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.Formal Name: 9,15-dioxo-prosta-10,13E-dien-1-oic acid. CAS Number: 61600-67-7. Synonyms: 15-keto PGA1. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/C(CCCCC)=O)C=C1. InChi Code: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-16,18H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,18+/m0/s1. InChi Key: YKXHFAJZOFTAOC-DTXSUPOZSA-N.