15-keto Fluprostenol isopropyl ester

15-keto Fluprostenol isopropyl ester is an ester derivative of the FP receptor agonist fluprostenol (Cay-16768) that is oxidized at carbon 15. It is a potential inactive metabolite of fluprostenol isopropyl ester (travoprost, Cay-16769) based on the published metabolism of latanoprost (Cay-16812) by 15-hydroxyprostaglandin dehydrogenase in the monkey cornea. 15-keto Fluprostenol isopropyl ester is a potential impurity found in commercial preparations of fluprostenol isopropyl ester.Formal Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid, 1-methylethyl ester. CAS Number: 404830-45-1. Synonyms: 15-keto Travoprost. Molecular Formula: C26H33F3O6. Formula Weight: 498.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 16 mg/ml. lambdamax: 224 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/C(COC2=CC(C(F)(F)F)=CC=C2)=O)[C@H](O)C1. InChi Code: InChI=1S/C26H33F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,21-24,31-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t21-,22-,23+,24-/m1/s1. InChi Key: KSDDYCRRTVADFZ-OHDKTVHDSA-N.