15-deoxy-Delta12,14-Prostaglandin J2-d4

15-deoxy-Delta12,14-PGJ2-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 15-deoxy-Delta12,14-PGJ2 by GC- or LC-mass spectrometry. 15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-Delta12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.Formal Name: 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic-3,3,4,4-d4 acid. CAS Number: 1542166-82-4. Synonyms: 15-deoxy-Delta12,14-PGJ2-d4. Molecular Formula: C20H24D4O3. Formula Weight: 320.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 50 mg/ml, Ethanol: 75 mg/ml, PBS pH 7.2: 2.7 mg/ml. lambdamax: 306 nm. SMILES: O=C1/C([C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)C=C1)=C/C=C/CCCCC. InChi Code: InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1/i8D2,11D2. InChi Key: VHRUMKCAEVRUBK-NSTSLKHFSA-N.