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Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.Formal Name: 13-[(2R,3S)-3-pentyloxiranyl]-5Z-tridecenoic acid. CAS Number: 519038-92-7. Synonyms: 14,15-Epoxyeicosa-5(Z)-enoic Acid. Molecular Formula: C20H36O3. Formula Weight: 324.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: CCCCC[C@H]1O[C@H]1CCCCCCC/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H36O3/c1-2-3-12-15-18-19(23-18)16-13-10-8-6-4-5-7-9-11-14-17-20(21)22/h7,9,18-19H,2-6,8,10-17H2,1H3,(H,21,22)/b9-7-/t18-,19+/m1/s1. InChi Key: KZTLOTWHEAHQAZ-VNULFWPXSA-N.
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