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Product information "13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4"
PGE1 is produced by the metabolism of dihomo-gamma-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM) and increases vasodilation.13,14-dihydro-16,16-difluoro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound. The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo. 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro PGE1-3,3',4,4'-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1 by GC- or LC-mass spectrometry (MS).Formal Name: 9-oxo-11alpha,15R,S-dihydroxy-16,16-difluoro-prostan-1-oic-3,3,4,4-d4 acid. Synonyms: 15-hydroxy Lubiprostone. Molecular Formula: C20H30D4F2O5. Formula Weight: 396.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: O=C1[C@H](CCCC([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](CCC(O)C(F)(F)CCCC)[C@H](O)C1. InChi Code: InChI=1S/C20H34F2O5/c1-2-3-12-20(21,22)18(25)11-10-15-14(16(23)13-17(15)24)8-6-4-5-7-9-19(26)27/h14-15,17-18,24-25H,2-13H2,1H3,(H,26,27)/t14-,15-,17-,18?/m1/s1/i5D2,7D2. InChi Key: PNVYHTHOCKTJCO-OQCFKNQOSA-N.
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