13,14-dihydro-15-keto Prostaglandin E2-d4

13,14-dihydro-15-keto Prostaglandin E2-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010606-25 25 µg -

3 - 10 business days*

118.00€
Cay10010606-50 50 µg -

3 - 10 business days*

224.00€
Cay10010606-100 100 µg -

3 - 10 business days*

423.00€
 
13,14-dihydro-15-keto Prostaglandin E2-d4 (13,14-dh-15-keto PGE2-d4) contains four deuterium... more
Product information "13,14-dihydro-15-keto Prostaglandin E2-d4"
13,14-dihydro-15-keto Prostaglandin E2-d4 (13,14-dh-15-keto PGE2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-keto PGE2 (Cay-14650) by GC- or LC-MS. 13,14-dh-15-keto PGE2 is the primary metabolite of PGE2 (Cay-14010) in plasma. Endogenous or infused PGE2 is rapidly metabolized by the enzymes 15-hydroxy PGDH and 15-oxo-PG Delta13-reductase to form 13,14-dh-15-keto PGE2. 13,14-dh-15-keto PGE2 accumulates to detectable levels, plasma levels in humans are between 10-100 pg/ml. It undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dh-15-keto PGE2 is about 9 minutes. In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE2 biosynthesis. Formal Name: 9,15-dioxo-11alpha-hydroxy-prost-5Z-en-1-oic-3,3,4,4-d4 acid. Synonyms: 13,14-dh-15-keto PGE2-d4. Molecular Formula: C20H28D4O5. Formula Weight: 356.5. Purity: >99% deuterated forms (d1-d4). Formulation: A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@H](CCC(CCCCC)=O)[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)C(C1)=O. InChi Code: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-17,19,23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,19-/m1/s1/i5D2,8D2. InChi Key: CUJMXIQZWPZMNQ-BQWYWOLISA-N.
Keywords: 13,14-dh-15-keto PGE2-d4, 9,15-dioxo-11alpha-hydroxy-prost-5Z-en-1-oic-3,3,4,4-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 10010606

Properties

Application: Standard
MW: 356.5 D
Formula: C20H28D4O5
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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