11-dehydro Thromboxane B2-d4

11-dehydro Thromboxane B2-d4 (TXB2-d4) is intended for use as an internal standard for the quantification of 11-dehydro TXB2 (Cay-19500) by stable isotope dilution MS. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis. The mean plasma level in human males is 0.9-4.3 pg/ml and the half life is 45-60 minutes.Formal Name: 9alpha,15S-dihydroxy-11-oxothromba-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. CAS Number: 1240398-15-5. Synonyms: 11-dehydro TXB2-d4, 11-keto TXB2-d4. Molecular Formula: C20H28D4O6. Formula Weight: 372.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >50 mg/ml, DMSO: >25 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >100 µg/ml. SMILES: O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)OC(C1)=O. InChi Code: InChI=1S/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1/i5D2,8D2. InChi Key: KJYIVXDPWBUJBQ-DDHOZZTNSA-N.