1-Palmitoyl-d3-2-hydroxy-sn-glycero-3-PC

1-Palmitoyl-d3-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC (Cay-10172) by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 µM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1beta, IL-12, and TNF-alpha in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 µM. It increases TGF-beta1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 µM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.Formal Name: (7R)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphapentacosan-25,25,25-d3-1-aminium, inner salt, 4-oxide. CAS Number: 2692624-19-2. Synonyms: 1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine-d3, 1-Hexadecanoyl-sn-glycero-3-Phosphocholine-d3, LPC-d3, 16:0/0:0(d3) Lyso-PC, 1-Palmitoyl-sn-glycero-3-Phosphocholine-d3, PC(16:0/0:0)-d3, 16:0/0:0-PC-d3. Molecular Formula: C24H47D3NO7P. Formula Weight: 498.7. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (1:1): soluble, DMF: soluble, DMSO: soluble, Ethanol: 2 mg/ml, PBS (pH 7.2): soluble. SMILES: O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COC(CCCCCCCCCCCCCCC([2H])([2H])[2H])=O. InChi Code: InChI=1S/C24H50NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24(27)30-21-23(26)22-32-33(28,29)31-20-19-25(2,3)4/h23,26H,5-22H2,1-4H3/t23-/m1/s1/i1D3. InChi Key: ASWBNKHCZGQVJV-MVIJBLFRSA-N.