1-Oleyl-2-hydroxy-sn-glycero-3-PA

1-Oleyl-2-hydroxy-sn-glycero-3-PA (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.Formal Name: 3-(octadecyloxy)-1-(dihydrogen phosphate)-1,2-propanediol. CAS Number: 52977-29-4. Synonyms: LPA O-18:0, O-18:0 LPA, 1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate, 1-Octadecyl LPA, 1-Octadecyl Lysophosphatidic Acid, 1-Oleyl LPA, 1-Oleyl Lysophosphatidic Acid, PA(O-18:0/0:0). Molecular Formula: C21H45O6P. Formula Weight: 424.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) ((1:1): 0.5 mg/ml. SMILES: CCCCCCCCCCCCCCCCCCOC[C@@H](O)COP(O)(O)=O. InChi Code: InChI=1S/C21H45O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26-19-21(22)20-27-28(23,24)25/h21-22H,2-20H2,1H3,(H2,23,24,25)/t21-/m1/s1. InChi Key: HUUYDUFSUADEJQ-OAQYLSRUSA-N. Side Chain Carbon Sum: 18:0.